Professional research subjects or duplicate subjects in clinical trials cause safety concerns and poor quality data. The Verified Clinical Trials global research subject database registry is a tool to detect duplicate subjects and prevents many protocol violations proactively at the time of screening. What we have learned from experience and analytical data review over the past 9 years is that there is no “typical” professional research subject. Both men and women, young and old, across many therapeutic areas do attempt to enroll in more than 1 clinical trial simultaneously. Certain therapeutic areas such as; healthy volunteers, psychiatry, pain, CNS, as well as metabolic that includes diabetes, inflammation/arthritis, women and men’s health are among the highest rates of attempts. Nearly every trial is at risk for duplicate subjects.